AMT Click Chemistry - AK Scientific
 
 


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Dual-Functional AMT Organoborons for Click Chemistry

Among click chemistry reactions, the Huisgen 1,3-dipolar cycloaddition of azides to alkynes to give 1,2,3-triazoles is, as Dr. Sharpless called it, "the cream of the crop".
AK Scientific stocks unique alkynes and azides with organoboron functionality from AMT, suited both for the Huisgen click reaction and for Suzuki coupling.
AMT Click Chemistry Fact Sheet

Azides

Catalog #
(structure)
Name

Alkynes

Catalog #
(structure)
Name

References

  1. Kolb, H. C.; Finn, M. G.; Sharpless, K. B. Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew. Chem., Int. Ed. 2001, 40, 2004-2021.
  2. Tron, G. C.; Pirali, T.; Billington, R. A.; Canonico, P. L.; Sorba, G.; Genazzani, A. A. Click Chemistry Reactions in Medicinal Chemistry: Applications of the 1,3-dipolar Cycloaddition between Azides and Alkynes. Med. Res. Rev. 2007, 28, 278-308.
  3. AMTB503: White, J. R.; Price, G. J.; Schiffers, S.; Raithby, P. R.; Plucinski, P. K.; Frost, C. G. A Modular Approach to Catalytic Synthesis Using a Dual-functional Linker for Click and Suzuki Coupling Reactions. Tetrahedron Lett. 2010, 51, 3913-3917.
  4. AMTB515: Mulla, K.; Dongare, P.; Zhou, N.; Chen, G.; Thompson, D. W.; Zhao, Y. Highly Sensitive Detection of Saccharides under Physiological Conditions with Click Synthesized Boronic Acid-Oligmer Fluorophores. Org. Biomol. Chem. 2011, 9, 1332-1336.
  5. AMTB514: Molander, G. A.; Ham, J. Synthesis of Functionalized Organotrifluoroborates via the 1,3-Dipolar Cycloaddition of Azides. Org. Lett. 2006, 8, 2767-2770.

See AMT's website or contact us for more info about AMT's unique compounds.